Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in Breast Cancer.
Hiroko K. SolvangOle Christian LingjærdeArnoldo FrigessiAnne-Lise Børresen-DaleVessela N. KristensenPublished in: BMC Bioinform. (2011)
Keyphrases
- breast cancer
- copy number
- expression profiles
- microarray
- dna copy number
- gene expression profiles
- gene networks
- gene expression
- protein protein interactions
- gene expression data
- single nucleotide polymorphisms
- genome wide
- signaling pathways
- logistic regression
- regulatory networks
- sequence data
- noise level
- gene sets
- gene regulatory networks
- high throughput
- microarray data
- microarray datasets
- gene ontology
- breast cancer patients
- high dimensionality
- cancer patients
- binding sites
- gene selection
- computational methods
- systems biology
- roc analysis
- computational approaches
- protein interaction
- transcription factors
- experimental conditions
- feature selection
- biological networks
- training set
- training data