Conserved Core Substructures in the Overlay of Protein-Ligand Complexes.
Barry C. FinzelRamprasad AkavaramAravind RagipindiJeffrey R. Van VoorstMatthew H. CahnMalcolm E. DavisMatt E. PokrossSteven SheriffEric T. BaldwinPublished in: J. Chem. Inf. Model. (2011)
Keyphrases
- protein complexes
- protein protein
- protein protein interactions
- protein interaction networks
- drug design
- protein interaction
- computational approaches
- ppi networks
- protein function
- functional modules
- sequence alignment
- virtual screening
- high throughput
- computational biology
- binding sites
- biological processes
- predicting protein
- genomic data
- computational methods
- protein protein interaction networks
- drug discovery
- protein sequences
- protein families
- protein structure prediction
- gene ontology
- biological networks
- protein structure
- structural motifs
- data structure
- substructure discovery
- interaction networks
- transcription factor binding sites
- biomedical literature
- critical points
- amino acids
- network topology
- high precision