A Maximum-Likelihood Formulation and EM Algorithm for the Protein Multiple Alignment Problem.
Valentina SulimovaNikolay RazinVadim MottlIlya B. MuchnikCasimir A. KulikowskiPublished in: PRIB (2010)
Keyphrases
- em algorithm
- maximum likelihood
- multiple alignment
- protein sequences
- multiple sequence alignment
- sequence alignment
- expectation maximization
- parameter estimation
- mixture model
- amino acids
- likelihood function
- computational biology
- protein structure
- hyperparameters
- maximum likelihood estimation
- generative model
- secondary structure
- maximum a posteriori
- gaussian mixture model
- penalized likelihood
- expectation maximisation
- memory efficient
- log likelihood function
- generalized em algorithm
- biological sequences
- sequential pattern mining
- probability density function
- sequence databases
- mining sequential patterns
- pairwise
- genetic algorithm
- graph theoretic
- maximum likelihood estimates
- sequential patterns
- dynamic programming
- data mining