Predicting Polypharmacology by Binding Site Similarity: From Kinases to the Protein Universe.
Francesca MillettiAnna VulpettiPublished in: J. Chem. Inf. Model. (2010)
Keyphrases
- binding sites
- protein protein
- virtual screening
- predicting protein
- dna binding
- protein interaction
- regulatory elements
- sequence alignment
- computational methods
- protein protein interactions
- dna sequences
- similarity measure
- similarity searching
- drug discovery
- gene expression
- sequence data
- transcription factor binding sites
- transcription factors
- protein sequences
- sequence similarity
- regulatory networks
- high throughput
- distance function
- motif discovery
- statistical significance
- protein families
- drug design
- similarity search
- machine learning
- interaction networks
- protein function
- data mining
- protein structure
- protein complexes
- protein interaction networks
- biological processes
- network analysis
- statistical analysis
- high dimensional
- semantic similarity
- statistically significant