Predicting Protein-Protein Interactions from Multimodal Biological Data Sources via Nonnegative Matrix Tri-Factorization.
Hua WangHeng HuangChris H. Q. DingFeiping NiePublished in: RECOMB (2012)
Keyphrases
- predicting protein protein interactions
- data sources
- nonnegative matrix tri factorization
- protein protein interactions
- biological data
- protein protein
- biological processes
- data integration
- molecular biology
- computational methods
- protein interaction
- protein complexes
- functional modules
- systems biology
- semi supervised
- interaction networks
- high throughput
- drug design
- biological networks
- binding sites
- protein sequences
- data model
- gene ontology
- data sets
- databases
- biomedical literature
- protein interaction data
- simultaneous clustering
- computational approaches
- protein structure
- protein interaction networks
- network topology
- dna sequences