Highly Sensitive and Specific Detection of Rare Variants in Mixed Viral Populations from Massively Parallel Sequence Data.
Alexander R. MacalaladMichael C. ZodyPatrick CharleboisNiall J. LennonRuchi M. NewmanChristine M. MalboeufElizabeth M. RyanChristian L. BoutwellKaren A. PowerDoug E. BrackneyKendra N. PeskoJoshua Z. LevinGregory D. EbelTodd M. AllenBruce W. BirrenMatthew R. HennPublished in: PLoS Comput. Biol. (2012)
Keyphrases
- sequence data
- massively parallel
- sequence classification
- fine grained
- parallel computing
- sequence analysis
- biological sequences
- profile hidden markov models
- nucleotide sequences
- parallel architectures
- high performance computing
- binding sites
- parallel computers
- genetic algorithm
- data analysis
- parallel machines
- distributed systems
- np hard
- blue gene
- information systems